Serial sacrifice study of pathogenesis of 210Po-induced lung tumors in Syrian golden hamsters.
نویسندگان
چکیده
The pathogenesis of 210Po-induced tumors in the peripheral lung of Syrian golden hamsters has been studied in a serial sacrifice experiment utilizing both plastic (glycol methacrylate) and routine paraffin embedding procedures for lung sections. A rapid progression from hyperplasia of bronchiolar-type cells that appear in the alveolar region to malignant tumors was documented. Tumors began appearing as early as 15 weeks after the first intratracheal instillation of 210Po.
منابع مشابه
The Induction of Melanotic Tumors Resembling Cellular Blue Nevi in the Syrian White Hamster by Cutaneous Application of 7,12-Dimethylbenz[a]anthracene*
Melanotic tumors resembling cellular blue nevi of man were induced in the Syrian white hamster by single and multiple applications of 7,1~-dimethylbenz[a]anthracene (DMBA). Histologically they resembled the melanotic tumors produced under similar experimental conditions in the Syrian golden hamster. They showed great variations in pigment content from almost nonpigmented to heavily pigmented tu...
متن کاملThe Effect of Concomitant Ethanol and Opium Consumption on Lipid Profiles and Atherosclerosis in Golden Syrian Hamster’s Aorta
Background: Cardiovascular disease (CVD) is the main cause of mortality in the world and is normally argued as the third cause of all mortalities. Opium and alcohol every day consumption can cause people to have many health problems. The present study aimed to assess the effect of ethanol and opium consumption on lipid profiles and atherosclerosis in aorta. Methods: Twenty four male golden Syri...
متن کاملDifferential susceptibility to bronchial carcinogenesis in syngeneic hamsters.
Previous studies of chemical carcinogenesis in the lung of Syrian golden hamsters have utilized outbred (nonsyngeneic) animals. Using the endobronchial sustained release implant technique, which causes focally originating cancers in outbred hamsters, we studied the course of bronchial carcinogenesis in two varieties of syngeneic Syrian golden hamsters, the LSH and the F1D strains (BIO 15.16 mal...
متن کاملDifferential Susceptibility to Bronchial Carcinogenesis in Syngeneic Hamsters1
Previous studies of chemical carcinogenesis in the lung of Syrian golden hamsters have utilized outbred (nonsyngeneic) animals. Using the endobronchial sustained release implant technique, which causes focally orig inating cancers in outbred hamsters, we studied the course of bronchial carcinogenesis in two varieties of syngeneic Syrian golden hamsters, the I SI I and the 1,1) strains (BIO 15.1...
متن کاملA Transplantable Induced Melanotic Tumor of the Syrian Golden Hamster*
The present paper records the availability of a new transplantable melanotic tumor in the Syrian golden hamster. A previous report (1) described the induction of multiple pigmented tumors in the Syrian golden hamster following the application to the skin of a single dose of the carcinogen 9,10dimethyl-l,2-benzanthracene. These tumors were sharply demarcated and located in the dermis and subcuta...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Cancer research
دوره 38 4 شماره
صفحات -
تاریخ انتشار 1978